Serotonin transporter gene variation and stressful life events impact processing of fear and anxiety
نویسندگان
چکیده
منابع مشابه
Interaction between serotonin transporter gene, catechol-O-methyltransferase gene and stressful life events in mood disorders.
It is well established that stress is a risk factor for onset of mood disorders. Emerging evidence suggests that genetic vulnerability may also moderate individual responsiveness to stress. The most compelling evidence regards the polymorphism within the promoter region of the serotonin transporter gene (SERTPR), which has been reported to moderate the risk for depression, in conjunction with l...
متن کاملTriangulating meta-analyses: the example of the serotonin transporter gene, stressful life events and major depression
BACKGROUND Meta-analysis is intended as a tool for the objective synthesis of evidence across a literature, in order to obtain the best evidence as to whether or not an association or effect is robust. However, as the use of meta-analysis has proliferated it has become increasingly clear that the results of a meta-analysis can be critically sensitive to methodological and analytical choices, so...
متن کاملSerotonin transporter gene and adverse life events in adult ADHD.
Childhood attention deficit hyperactivity disorder (ADHD) symptomatology persists in a substantial proportion of cases into adult life. ADHD is highly heritable but the etiology of ADHD is complex and heterogeneous, involving both genetic and non-genetic factors. In the present article we analyzed the influence of both genetics and adverse life events on severity of ADHD symptoms in 110 adult A...
متن کاملLife events, first depression onset and the serotonin transporter gene.
BACKGROUND A relationship between the serotonin transporter gene, adverse events and onset of major depression has been reported. AIMS To replicate a gene x environment interaction in a cohort with longitudinal data for life events, experience of depression, parental bonding and neuroticism. METHOD At the 25-year follow-up, genomic DNA was obtained from 127 cohort members (mean age 48 years...
متن کاملThe relationship between stressful life events, the serotonin transporter (5-HTTLPR) genotype and major depression.
BACKGROUND Serotonin is a good candidate for major depression. We attempted to replicate the study by Caspi and colleagues [Science (2003) 301, 386-389] which reported a significant interaction between serotonin transporter (5-HTTLPR) genotype and stressful life events when predicting major depression. METHOD We typed the serotonin promoter 5-HTTLPR gene in 1206 male and female twins aged 19-...
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ژورنال
عنوان ژورنال: The International Journal of Neuropsychopharmacology
سال: 2008
ISSN: 1461-1457,1469-5111
DOI: 10.1017/s1461145708009565